When Cheetah escapes from the A.R.G.U.S. prison, she finds a map to Pandora's Box among the ancient artefacts that A.R.G.U.S. protects, and sets out to find it, hoping it has the power to make her human again--but Wonder Woman knows that Pandora's Box does not work that way, and it is imperative to stop Cheetah before she unleashes destruction on the world.

When she seizes a piece of an ancient wand from the Servants of Evil, Wonder Woman discovers that it is infused with dark magic, and during her quest for the remaining pieces she realizes that the wand belongs to the evil Circe, who must be the Servants mysterious master--but when she brings the pieces to the Museum of Natural History in Washington, D.C., she discovers that some of the people she trusts are not what they seem.

Wonder Woman is taking the Golden Shield of Dolos, a gift from the trickster god, Dolos, to the Gateway City Museum of Antiquities, but when Gorilla Grodd steals it, she finds herself teaming up with the villain Giganta, who wants revenge on the Gorilla--and has plans of her own for the magical shield.